Part I • Basic Hematology Principles

Part I • Basic Hematology Principles

RSC'RET IP VEisagE(ii[ PLT IP MsssagefEj Figure 2.6 Sample CBC.

• Normochromic normocytic anemia

• Microcytic hypochromic anemia

• Macrocytic normochromic anemia

A normocytic normochromic anemia implies a normal red cell MCV (80 to 100 fL) and normal Hgb content of red cells (MCHC of 32% to 36%). Although the red cell and Hgb values may be reduced in this anemia, the size and Hgb content per cell are in the normal range. Red cells are normal size with a normal Hgb content. A microcytic hypochromic anemia implies an MCV of less than 80 fL with an MCHC of less than

32%. In this blood picture, the red cells are microcytic and smaller and lack Hgb, having an area of central pallor much greater than the usual 3-pm area. A macrocytic normochromic anemia implies an MCV of greater than 100 fL. Red cells are larger than 8 pm with an Hgb content in the normal range. If an anemia is suspected and confirmed by a CBC, the peripheral smear picture should reflect the morphological classification generated by automated results. For example, a patient sample with an MCV of 67 fL and an MCHC of 30% should have red cells that are small and pale. If the peripheral smear results do not correlate with the auto-

Table 2.3 O Normal Values Using SI Units

Females 4.2 to 5.4 X 1012/L Hgb Males 14 to 18 g/dL

Females 12 to 16 g/dL Hct Males 42% to 52%

Females 37% to 47% MCV 80 to 100 fL

MCH 27 to 31 pg

Platelet count 150,000 to 350,000 X 109/L

mated results, an investigation should be initiated to determine the cause of the discrepancy. A detailed explanation of anemias under each morphological classification follows in the subsequent chapters.

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