After completing this chapter, the student will be able to:

1. Compare and contrast acute versus chronic leukemia with respect to age of onset, presenting symptoms, and organ involvement.

2. Describe acute leukemia with emphasis on symptoms, peripheral smear finding, and bone marrow findings.

3. Classify the acute nonlymphocytic leukemias according to the French-American-British classification system.

4. Describe how cytochemical staining can aid in the diagnosis of the acute leukemias.

5. Briefly describe the World Health Organization classification for acute leukemias.

6. Identify the most consistent cytogenetic abnormalities in the acute leukemias.

7. Describe acute lymphocytic leukemia with emphasis on age of onset, symptoms at presentation, prognosis, and laboratory findings.

8. Describe the most pertinent CD markers for the acute lymphocytic leukemias.

9. Describe the factors that may influence the prognosis in acute lymphocytic leukemias.

10. Characterize the T-cell acute lymphoblastic leukemias.

160 Part III • White Cell Disorders

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