Objectives

After completing this chapter, the student will be able to:

1. Define the quantitative platelet disorders.

2. Identify the types of bleeding that are seen in platelet disorders.

3. List four laboratory tests that are helpful in evaluating platelet disorders.

4. State how preanalytic variables may affect the platelet count.

5. Describe three characteristics of the qualitative platelet disorders von Willebrand disease, Bernard Soulier, and Glanzmann's thrombas-thenia.

6. Identify drugs that are implicated in immune thrombocytopenia.

7. Evaluate conditions that may cause thrombocytosis.

8. Compare and contrast acute versus chronic idiopathic thrombocytopenic purpura.

9. Describe the effect of ristocetin on platelet aggregation.

10. Define hemolytic uremic syndrome in terms of incidence, key clinical features, and patient management.

11. Define thrombotic thrombocytopenic purpura in terms of incidence, key clinical features, and severity.

12. Describe platelet abnormalities due to acquired defects: drug induced, nonimmune, or vascular.

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