After completing this chapter, the student will be able to:

1. Describe the variable types of bleeding found in patients with clotting factor deficiencies versus platelet disorders.

2. Define the factor VIII molecule.

3. Outline the genetics of the hemophilia disorders.

4. Describe the symptoms of an individual with hemophilia A and B.

5. Define the laboratory results in an individual with hemophilia A and B.

6. Describe the management and treatment of an individual with hemophilia A and B.

7. Distinguish the clotting factor disorders with little or no bleeding.

8. Distinguish the acquired factor disorders with regard to symptomatology and treatment.

Evaluation of a Bleeding Disorder and Types of Bleeding

The Classic Hemophilias

The Factor VIII Molecule

Symptoms in the Hemophilia A patient

Laboratory Diagnosis of Hemophilia Patients

Treatment for Hemophilia A Patients

Quality of Life Issues for Hemophilia A Patients

Hemophilia B or Christmas Disease

Congenital Factor Deficiencies With Bleeding Manifestations

Congenital Factor Deficiencies Where Bleeding Is Mild or Absent

Factor XIII Deficiency

Bleeding Secondary to a Chronic Disease Process The Role of Vitamin K in Hemostasis Vitamin K Deficiency and Subsequent Treatment

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