Plasma Cell Disorders

Normal Plasma Cell Structure and Function

A normal plasma cell evolves as the last stage of a B lymphocyte. In structure and function, this is a unique cellular entity that comprises less than 5% of the cells in the bone marrow. Rarely do these cells make an appearance in the peripheral circulation, and when they do, they are in response to infectious, inflammatory conditions, or malignant proliferation (Table 13.3). A plasma cell is a medium-sized cell with an eccentric nucleus having a well-defined Golgi apparatus. Of particular

Table 13.3

Increased Plasma

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