Tc Ii

Ileum

Ileum

Ileum

Figure 6.3 Vitamin B12 absorption and transport. Vitamin B12 must be combined with intrinsic factor (IF) before it enters the blood circulation: transcobalamin II (TC II) is the transport protein that carries vitamin B12 to the tissues.

Figure 6.3 Vitamin B12 absorption and transport. Vitamin B12 must be combined with intrinsic factor (IF) before it enters the blood circulation: transcobalamin II (TC II) is the transport protein that carries vitamin B12 to the tissues.

inside the tissues, the methyl group is released to combine with homocysteine, an early precursor to DNA synthesis. Homocysteine is converted to methionine, an amino acid. If folate or vitamin B12 metabolism is flawed, homocysteine will accumulate and can potentially lead to thrombosis,3 a potential consequence to the hemostatic system that is just being realized.

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