Word Key

Auer rods • Elliptical, spindle-like inclusions com posed of fused azurophilic granules that may be present in myeloblasts, monoblasts, or promyelocytes in the various AMLs

Cytochemistry • Special stains usually performed on bone marrow samples that are examined microscopically to identify enzymes, lipids, or other chemical constituents within the blast population of cells in acute leukemia

Dyspnea • Shortness of breath

Dysplasia • Abnormal maturation of cells in the bone marrow

Gingival hyperplasia • Swelling of the gingival tissues (gums); in leukemia, this is due to infiltration of the gum tissues with leukemic cells

Immunophenotyping • Process of using monoclonal antibodies directed against cell surface markers to identify antigens unique to the specific lineage and stage of maturation

Lineage • Referring to one specific cell line

Lymphoma • Neoplasm involving abnormal proliferation of cells arising in the lymph nodes; these tumor cells may also metastasize to involve extranodal sites

Meningeal leukemia • Leukemic cells proliferating in the central nervous system

Myelodysplasia • Abnormal maturation and/or differentiation of granulocytes, erythrocytes, monocytes, and platelets

Oncogene • Gene that is responsible for the development of cancer

References

1. Virchow R. Weisses Blut Froiep's Notizen 36:151, 1845.

2. Bennett JH. Two cases of disease and enlargement of the spleen in which death took place from the presence of purulent matter in the blood. Edinburgh Med Surg J 64:413, 1845.

3. Virchow R. Die farblosen Blutkorperchen. In: Gesammelte Abhandlungen sur Wissen schaftlichen Medizin. Frankfurt: Meidinger, 1856.

4. Neumann E. Ueber myelogene leukäemie. Berl Klin Wochenchr 15:69, 1878.

5. Ebstein W Ueber die acute Leukämie und Pseudoleukämie. Dtsch Arch Klin Med 44:343, 1889.

6. Erlich P Farbenanolytische Untersuchungen zur Histologie und Klinik des Blutes. Berlin: Hirschwald, 1891.

7. Naegeli O. Ueber rothes Knochenmark und Myeloblasten. Dtsch Med Wochenschr 26:287, 1900.

8. Hirschfield H. Zur Kenntnis der Histogenese der gran-ulirten Knochenmarkzellen. Arch Pathol Anat 153:335, 1898.

9. Look AT. Oncogene transcription factors in human acute leukemias. Science 278:1059, 1997.

10. Harmening DH. Clinical Hematology and Fundamentals of Hemostasis, 4th ed. Philadelphia: FA Davis, 2002.

11. Sandler DP, Ross JA. Epidemiology of acute leukemia in children and adults. Semin Oncol 24:3-16, 1997.

12. Caldwell GG, Kelley D, Zack M, et al. Mortality and cancer frequency among military nuclear test (SMOKY) participants 1957 through 1979. JAMA 250:620-624, 1983.

13. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and Effects of Ionizing Radiation. Publication E.94.IX.2, New York: United Nations, 1972.

14. Sullivan AK. Classification, pathogenesis, and etiology of neoplastic diseases of the hematopoietic system. In: Lee GR, Bithell TC, Foerster J, et al, eds. Wintrobe's Clinical Hematology, 9th ed. Philadelphia: Lea and Febiger, 1993: 1725-1791.

15. Chang JC. How to differentiate neoplastic fever from infectious fever in patients with cancer. Usefulness of naproxen test. Heart Lung 16:122, 1987.

16. Golub TR, Weinstein HJ, Grier HE. Acute myelogenous leukemia. In: Pizzo P, Poplack D, eds. Principles and

184 Part III • White Cell Disorders

Practice of Pediatric Oncology, 3rd ed. Philadelphia: JB Lippincott, 1997: 463-482.

17. Rohatiner A, Lister TA. The general management of the patient with leukemia. In: Henderson ES, Lister TA, Greaves MF, eds. Leukemia, 6th ed. Philadelphia: WB Saunders, 1996: 247-255.

18. Burns CP, Armitage JO, Frey AL, et al. Analysis of presenting features of adult leukemia. Dancer 47:2460, 1981.

19. Jaffe ES, Harris NL, Stein H, et al. World Health Organization Classification of Tumours; Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.

20. Traweek ST, Arber DA, Rappoport H, et al. Extramedullary myeloid tumors. An immunohisto-chemical and morphologic study of 28 cases. Am J Surg Pathol 17:1011-1019, 1993.

21. Chilosi M, Pizzolo G. Review of terminal deoxynu-cleotidyl transferase. Biologic aspects, methods of detection, and selected diagnostic application. Appl Immunohistochem 3:209-221, 1995.

22. Kung PC, Long JC, McCaffrey RP, et al. Tdt in the diagnosis of leukemia and malignant lymphoma. Am J Med 64:788, 1978.

23. Marks SM, Baltimore D, McCafffrey R. Terminal trans-ferase as a predictor of initial responsiveness to vin-cristine and prednisone in blastic chronic myelogenous leukemia. A cooperative study. N Engl J Med 298:812, 1978.

24. Harris NL, Jaffe ES, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November, 1997. J Clin Oncol 17:3835-3849, 1999.

25. Caligiuri MA, Strout MP, Gilliland DG. Molecular biology of acute myeloid leukemia. Semin Oncol 24:32-34, 1997.

26. Stark B, Resnitzky P, Jeison M, et al. A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:13), in a patient with the variant t(8:19)(p11:q13) - case report and review of the literature. Leuk Res 19:367-379, 1995.

27. Stanley M, McKenna RW, Ellinger G, et al. Classification of 358 Cases of Acute Myeloid Leukemia by FAB Criteria; Analysis of Clinical and Morphologic Findings in Chronic and Acute Leukemias in Adults. Boston: Martin Nijhoff Publishers, 1985.

28. Head DR. Revised classification of acute myeloid leukemia. Leukemia 10:1826-1831, 1996.

29. Leith CP, Kopecky KJ, Godwin J, et al. Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 89:3323-3329, 1997.

30. Pui CH, Relling MV, Rivera GK, et al. Epipodophyl-lotoxin-related acute myeloid leukemia: A study of 35 cases. Leukemia 9:1990-1996, 1995.

31. Ellis M, Ravid M, Lishner M. A comparative analysis of alkylating agent and epipodophyllotoxin-related leukemias. Leuk Lymphoma 11:9-13, 1993.

32. Scott CS, Stark AN, Limbert HJ, et al. Diagnostic and prognostic factors in acute monocytic leukemia: An analysis of 51 cases. Br J Haematol 69:247-252, 1988.

33. Finaux P, Vanhaesbroucke C, Estienne MH, et al. Acute monocytic leukaemia in adults: Treatment and prognosis in 99 cases. Br J Haematol 75:41, 1990.

34. Brunning RD, McKenna RW Acute leukemias. In: Atlas of Tumor Pathology. Tumors of the Bone Marrow. Washington, DC: Armed Forces Institute of Pathology, 1994: 19-142.

35. Davey FR, Abraham N Jr, Bronetto VL, et al. Morphologic characteristics of erythroleukemia (acute myeloid leukemia; FAB-M6): A CALGB study. Am J Hematol 49:29, 1995.

36. Bernstein J, Dastugue N, Haas OA, et al. Nineteen cases of the t(1;22)(p13;q13) acute megakaryoblas-tic leukaemia of infants/children and a review of 39 cases: Report from a t(1;22) study group. Leukemia 14:216-218, 2000.

37. Nichols CR, Roth BJ, Heerema N, et al. Hematologic neoplasms associated with primary mediastinal germ-cell tumors. N Engl J Med 322:1425-1429, 1990.

38. Bowman WP, Melvin SL, Aur RJ, et al. A clinical perspective on cell markers in acute lymphocytic leukemia. Cancer Res 41:4752-4766, 1981.

39. Hanson CA, Abaza M, Sheldon S, et al. Acute bipheno-typic leukaemia: Immunophenotypic and cytogenetic analysis. Br J Haematol 84:49-60, 1993.

40. Legrand O, Perrot JY, Simonin G, et al. Adult bipheno-typic acute leukaemia: An entity with poor prognosis which is related to unfavorable cytogenetics and P-glycoprotein over-expression. Br J Haematol 100: 147-155, 1998.

41. Matutes E, Morilla R, Farahat N, et al. Definition of acute biphenotypic leukemia. Haematologica 82: 64-66, 1997.

42. Gurney JG, Davis S, Serverson RK, et al. Trends in cancer incidence among children in the U.S. Cancer 78:532, 1996.

43. SEER Cancer Statistics Review, 1973-1995. Bethesda, MD: National Cancer Institute, 1998.

44. Reaman GH, Sposto R, Sensel MG, et al. Treatment outcome and prognostic factors for infants with acute lym-phoblastic leukemia treated on two consecutive trials of the Children's Cancer Group. J Clin Oncol 17:445, 1999.

45. Greaves MF. Aetiology of acute leukaemia. Lancet 349:344, 1997.

46. Kinlen LJ. High-contact paternal occupation, infection and childhood leukaemia: Five studies of unusual population mixing of adults. Br J Cancer 76:1539, 1997.

47. Ingram L, Rivera GK, Shapiro DN. Superior vena cava syndrome associated with childhood malignancy: Analysis of 24 cases. Med Pediatr Oncol 18:476, 1990.

48. Borowitz MJ, Croker BP, Metzgar RS. Lymphoblastic lymphoma with the phenotype of common acute lymphoblastic leukemia. Am J Clin Pathol 79:387-391, 1983.

49. Weiss LM, Bindl JM, Picozzi VJ, et al. Lymphoblastic lymphoma: An immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. Blood 67:474-478, 1986.

50. Look AT. Oncogenic transcription factors in the human acute leukemias. Science 278:1059, 1997.

51. Reiter A, Schrappe M, Tiemann M, et al. Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: A report of the Berlin-Frankfurt-Munster group trial NHL-BFM90. Blood 94:3294, 1999.

52. Bowman W, Shuster JJ, Cook B, et al. Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: A Pediatric Oncology Group study. J Clin Oncol 14:1252, 1996.

53. Smith M, Arthur D, Camita B, et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 14:18, 1996.

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