The history of tuberculosis in the United States

Although collection of cause-specific mortality data in the US began in 1900, data from all states were not included until 1933. A rate of 'new' cases of tuberculosis FIG. 2. Funding by the Centers for Disease Control for tuberculosis control. FIG. 2. Funding by the Centers for Disease Control for tuberculosis control. was determined annually beginning in 1930 but this figure did not become an accurate reflection of disease incidence until 1952 when inactive cases were no longer included. As...

References

Abbas AK, Murphy KM, Sher A 1996 Functional diversity of helper T lymphocytes. Nature 383 787-793 Actor JK, Shirai M, Kullberg MC, Buller RM, Sher A, Berzofsky JA 1993 Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci USA 90 948-952 Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM 1997 Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol 15 125-154 Allen JE, Maizels...

The immunopathology of tuberculosis

Immunity to M. tuberculosis requires a T helper 1 (Thl) pattern of response accompanied by several types of cytotoxic T cell (Flynn et al 1993,1995a,b, Rook & Hernandez-Pando 1996). A Th2 response is disastrous even a small Th2 component exacerbates the infection in mice (Lindblad et al 1997, Rook & Hernandez-Pando 1996). Thus, if the animals are pre-immunized so that they have a 'pure' Th1 response to culture filtrate antigens of M. tuberculosis, or to the common antigens present in a...

Antibiotic resistance in mycobacteria

Department of Microbiology and Immunology, University of British Columbia, 300-6170 University Boulevard, Vancouver, BC Canada V6T 1Z3 .Abstract. Multiple drug resistance in mycobacteria compromises the use of antibiotics. Although the genetic and biochemical bases of antibiotic resistance in mycobacteria are largely understood, a number of questions remain to be addressed. This chapter discusses the potential roles of hypermutability and compensatory mutations in establishing stable resistant...