Natural Nasal Polyps Cures
The clinical presentation of AFS can be similar to CRS. Patients often report chronic nasal congestion and nasal obstruction that has failed to respond to antibiotic therapy. Examination of the nasal cavity may reveal nasal polyps within the olfactory cleft, middle meatus, and sphenoethmoid recess. Occasionally, locally destructive changes from longstanding polyposis lead to proptosis and malar flattening (7). AFS is unilateral in more than 50 of patients but may involve several sinuses bilaterally, and bone erosion and extrasinus extension have been reported. The allergic mucin characteristic of this condition is thick and glue-like, with a heterogeneous brown appearance that has been compared to peanut butter.
Patients with this syndrome, pansinusitis is common. Although nasal polyps may complicate ordinary allergic rhinitis (approximately 1-2 in some studies) and are a common manifestation of cystic fibrosis (up to 50 of such patients), the highest incidence of nasal polyps occurs in the patients with NSAID hypersensitivity (up to 90 ). Such polyps often respond to systemic steroid treatment but may recur within days of its cessation. The clinical diagnosis of NSAID hypersensitivity can be made from the above-noted manifestations, particularly in patients with rhinorrhea, eosinophilia, nasal polyps, pansinusitis, and asthma. It may be suspected in patients with urticaria angioedema and considered in patients experiencing anaphylaxis. Unfortunately, no easily administered test or laboratory procedure can make this diagnosis. Currently, in the United States, the only test reagents available for diagnosis are the COX-1 inhibitors. Challenge via the oral route, in a graded manner beginning...
Another complication of untreated IgE-mediated nasal disease is the development of nasal polyps. Because they are a characteristic finding in the syndrome of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity, this topic will be dealt with in that section below.
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