Acyclovir

Trade name: Zovirax™ (among many others) Drug class: virostatic

Manufacturer: manufactured by several companies. Generics are generally cheaper than the originally introduced formulation (Zovirax™). Indications: treatment and prophylaxis of HSV and VZV infections.

Dose: for genital HSV infection: 400 mg po 5x/day for 7 days. In severe cases (ulcerating genital herpes) intravenous treatment with 5-10 mg/kg iv tid. For HSV encephalitis or HSV esophagitis 10 mg/kg iv tid.

For dermatomal herpes zoster 800 mg po 5x/day for 7 days. In cases of disseminated or complicated herpes zoster 10 mg/kg iv tid.

Side effects: rare. Headache, nausea and elevation of creatinine may occur. Phlebitis can occur with intravenous dosing.

Comments/Warnings: Initiation of treatment for HSV should be within the first 24 hours after appearance of symptoms if possible, for VZV within the first 4 days. Adequate fluid intake is important.

Internet sources:

USA: http://hiv.net/link.php?id=55 References:

1. Conant MA, Schacker TW, Murphy RL, et al. Valaciclovir versus aciclovir for herpes simplex virus infection in HIV-infected individuals: two randomized trials. Int J STD AIDS 2002, 13:12-21. http://amedeo.com/lit.php?id=11802924

2. Gnann JW Jr, Whitley RJ. Clinical practice. Herpes zoster. N Engl J Med 2002, 347:340-6.

3. Ioannidis JP, Collier AC, Cooper DA, et al. Clinical efficacy of high-dose acyclovir in patients with HIV infection: a meta-analysis of randomized individual patient data. J Infect Dis 1998, 178:349-59. http://amedeo.com/lit.php?id=9697714

4. Wagstaff AJ, Faulds D, Goa KL. Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1994; 47:153-205. http://amedeo.com/lit.php?id=7510619

Agenerase™ see Amprenavir Ambisome™ see Amphotericin B

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