Combinations that we currently recommend for first-line therapy (as of January 2007) are shown in Table 6.1.
Table 6.1: Combinations suitable for initial HIV therapy (not in order of preference!) NRTIs NNRTI/PI
*TDF + 3TC Lopinavir/ritonavir
*TDF + FTC plus either Fosamprenavir/ritonavir
AZT + 3TC Saquinavir/ritonavir
* Convincing data only on combination with efavirenz.
** Combination with NNRTIs without HLA typing, may be problematic due to allergies.
*** Caution should be taken in women of child-bearing age (teratogenicity)
**** Caution with high CD4-cell counts (women > 250/|jl, men > 400/|jl) because of hepa-totoxicity.
Moreover, numerous other combinations are, of course, possible and licensed. These combinations are certainly not wrong, and may be acceptable in individual cases or in investigational studies, but general recommendations for their use cannot be given. Problematic combinations, that are not advisable for use, are listed at the end of this chapter.
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