Phytoestrogens Make Breasts Grow

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Dietary phytoestrogens, plant substances that are structurally or functionally similar to estrogen, have been proposed to act as estrogen antagonists in breast, prostate, and endometrial cells. However, epidemiological studies of dietary phytoestrogens and breast cancer have been inconclusive. Some studies indicate that soy intake may reduce a woman's risk of premenopausal breast cancer 77-79 however, at least one study found no association between dietary soy and breast cancer.80 One study has also reported a decrease in risk for postmenopausal breast cancer.79 Ingram et al.81 re-examined the association between phytoestrogens and breast cancer by measuring urinary excretion rates of two classes of phytochemicals and found that an inverse relationship exists with the risk of both pre and postmenopausal breast cancer and urinary excretion. It remains untested whether the measured phytochemicals actually serve as markers of other correlated dietary components, such as fiber, which also...

The use of functional foods to meet dietary guidelines

Isoflavones (phytoestrogens) A high consumption of soy and soy protein has been associated with a low risk of CVD in ecological studies. Besides soy protein, phytoestrogens such as genistein might be responsible for the effects on CVD risk. Phytoestrogens comprise several groups of non-steroidal oestrogens including isoflavones and lignans. There is limited quantitative data on the absorption and metabolism of dietary phytoestrogens. Although it is now known that dietary phytoestrogens are metabolised by intestinal bacteria, absorbed, conjugated in the liver, circulated in plasma and excreted in urine, further clinical trials should determine the potential health effects of these compounds.42'43 Functional foods with isoflavones and other phytoestrogens include breakfast cereals, soft drinks, bakery and dairy products and snack bars.44

Reaching beyond Researchers

Other resources explain particular age-related diseases. The Centers for Disease Control Cardiovascular Health site contains information for lay people such as fact sheets on topics that include cholesterol, heart attacks, and high blood pressure. Of particular interest to researchers are the interactive maps that supply heart attack and stroke mortality rates for the state, gender, and racial ethnic group of choice. The site includes a list of Morbidity and Mortality Reports that relate to cardiovascular disease as well as other statistical and public-health information. NIH's Osteoporosis and Related Bone Diseases-National Resource Center offers background articles on topics of interest to researchers as well as lay people these include ''Vitamin A and Bone Health,'' ''Phytoestrogens and Bone Health,'' and ''Bone Mass Measurement What the Numbers Mean.''

An unkind note on sociobiology or evolutionary psychology

Playmates and porn stars usually have large breasts, either naturally or with the help of appropriate surgery and plastic materials, and large breasts are more attractive than small ones (Gitter et al., 1983 Singh and Young, 1995 Furnham et al., 1998). Sociobiology, just as the German philosopher Schopenhauer did more than 150 years ago (Schopenhauer, 1844), tells us that it is because large breasts assure abundant food for the infant. Schopenhauer also discussed the role of other characteristics of the female body contributing to its attractiveness, including what we now would call the body mass index. Within sociobiology, the body mass index is an indicator of good genes competing in importance with the waist to hip ratio (Tovee et al., 1999, 2002 Furnham et al., 2005). If nothing else, the similarity between the ideals of beauty or attractiveness put forth by an 19th century philosopher and present day sociobiologists shows that they are firmly rooted in Western culture. Moreover,...

Project Title Cvd Risk Health In Postmenopausal Phytoestrogen Users

Summary (Adapted from Investigator's Abstract) In the United States, heart disease is the leading cause of death in postmenopausal women. Estrogen replacement therapy is beneficial for heart disease risk factors as well as for bone density. However, a large proportion of postmenopausal women are not compliant with therapeutic regimens. Phytoestrogens are naturally occurring compounds found in plants and soy products that have estrogenic effects, and may represent an alternative treatment for the prevention of heart disease and osteoporosis in postmenopausal women. However, few intervention trials have examined the extent to which it is possible to improve heart disease risk factors, bone density, and quality of life in postmenopausal women through use of a dietary supplement of Phytoestrogen. The proposed randomized, double-blind, placebo controlled study is designed to determine the acceptability and benefits of use of a dietary supplement of Phytoestrogen (genistein) versus placebo...

Xenobiotic Pesticides

Both natural and synthetic environmental estrogens mimic the estrogenic activity of steroid hormones. Dietary phytoestrogens, as discussed above, have been proposed to act as estrogen antagonists in breast cells, potentially protecting these tissues from cancer formation. In contrast, xenobiotics, environmental estrogens such as pesticides, have been proposed to act as estrogen agonists, possibly increasing the risk of cancer formation. Although we would expect that a weak estrogen, whether from natural or synthetic sources, would act in a similar manner when applied to the same system, the effect is difficult to predict due to variable characteristics of the estrogen-like substances and the test systems. If the mechanism of action of environmental estrogens on cancer risk is strictly hormonal, it is unlikely that estrogenic pesticides and dietary phytoestrogens would exclusively produce opposite effects. Evaluation of in vitro and in vivo work for both phytoestrogens and xenobiotics...

Consumption of soybean and reduced incidence of disease

Isoflavonoids are a unique subgroup of the flavanoids, one of the largest classes of plant phenolics, with more than 5000 compounds currently identified. Isoflavonoids are found mainly in soybeans, and possess a chemical structure that is similar to the hormone estrogen (1). The chief isoflavonoids found in soybeans are genistein and daidzein. Because their structures resemble estrogen and they can interact with the estrogen receptor, soybean isoflavonoids are sometimes referred to as phytoestrogens (17). Phytoestrogens and Postmenopausal Activity The structure of soybean isoflavonoids is uniquely similar to that of estrogen (17) and may account for their weak ability to act as agonists at estrogen receptors (38). Many have speculated that soybean isoflavonoids may be useful for the treatment of somatic, mood, and cognitive disturbances associated with the onset of menopause (39). Diet supplementation with soybean phytoestrogens has been reported to ameliorate hot flashes and...

Materials and Methods

Three-week old female ACI rats were obtained from Harlan Sprague-Dawley and immediately allowed free access to the AIN-76A diet (AIN) or AIN supplemented with 250 ppm GEN, their prepubertal diet. The AIN diet is a casein-based, open formula purified diet that contains nondetectable levels of phytoestrogens. At 9 weeks of age, they were subcutaneously implanted in the shoulder region with a 20 mg pellet containing either cholesterol or cholesterol as previously

Dietary Prostate Cancer Risk Factors

Phytoestrogens Phytoestrogens, i.e., plant-derived estrogens such as from soy products, have been hypothesized to protect against prostate cancer, possibly by antagonist actions of estrogens on androgen-mediated growth.19 There are some experimental animal data supporting an inhibitory effect of phytoestrogen intake on prostate tumor growth.19,20 Phytoestrogen intake has been hypothesized to play a role in the reduced prostate cancer rates observed in Asian populations. Cross-sectional population studies have shown urinary phytoestrogen biomarkers to be substantially higher in native Japanese than other racial ethnic groups, but there is little direct evidence linking high phytoestrogen consumption to low prostate cancer risk.21 One study found tofu consumption, a soy source of phytoestro-gens, to be associated with reduced risk but there is great need for further epidemiological investigations.22

Isoflavones and coronary heart disease

Isoflavones are non-nutrient plant components, which belong to the phytoestrogen family (Kurzer and Xu, 1997). Phytoestrogens are diphenolic compounds. Ring A and Ring B are separated by a heterocyclic pyrone ring and have a similar chemical structure to mammalian oestrogens (see Figs 10.1 and 10.2). Comparison of the chemical structure of 17 3-estradiol and equol, a gut metabolite of daidzein (a major food isoflavone), indicates that the two compounds are almost super-imposable (Fig. 10.2).

Visual incentive stimuli

A few rather old studies tried to match men's preferences for certain female body types with personality characteristics. They did not directly address the issue of sexual incentive properties of the body shapes, but the aspects of body shape that were evaluated seem to be those considered sexual incentives at the time and perhaps also at present. These aspects were breast size, buttock size and leg thickness. Furthermore, it was maintained that contemporary society, that is American society in the 1960s, classified men as Breast Men, Buttock Men and Leg Men, according to which part of the female body they gave most importance. In an amusing study, men were asked to make pairwise comparisons of all possible combinations of silhouettes of nude women with varying breast sizes, buttock sizes and leg thickness. The results were subjected to a most complex statistical analysis, which allowed for the identification of five groups of men. The first group is those preferring women with ample...


Vegetables may protect against cancer, not through their fibre content, but as a result of a number of potential anticancer agents that they contain (e.g. phytoestrogens for breast, ovarian and endometrial cancers). Phytoestrogens include isoflavi-noids and lignans. Isoflavinoids are diphenolic compounds found in leguminous vegetable - soya and other beans, chickpeas and plants lignans, which are also diphenolic compounds, are formed by microflora in the gut from complex precursors found in vegetables. Both contain a number of conjugated weak oestrogens which, following ingestion, are deconjugated to active forms which are absorbed and excreted in the urine and faeces. As their concentration in body tissues is many times greater than that of endogenous oestradiol, they successfully compete for binding to the oestrogen receptor, suppressing endogenous oestrogen action. Dietary dipheno-lics are antioxidants and scavenge-free radicals.

Estrogen Signaling

Additional studies focusing on food benefits have identified a number of phytoestro-gens, compounds found in plants that have both agonistic and antagonistic effects on the estrogen receptors. These phytoestrogens include the lignans found in flaxseed, the coumestans in alfalfa sprouts, and the polyphenolic catechins found in teas (63). Chemopreventative studies in rodents examining phytoestrogens indicate that at high concentrations, these agents can impart protection in the mammary gland, which can be hoped will translate into human chemoprotection.

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