Hypothalamic Lesions

Lesions in the hypothalamus and pituitary stalk affect GH secretion in humans. Magnetic resonance imaging of the central nervous system in subjects with hypopituitarism demonstrate an increased incidence of anterior lobe hypoplasia, attenuation or transec-tion of the pituitary stalk, and formation of an ectopic posterior pituitary lobe at the base of the hypothalamus (41,42). Pituitary stalk transection or total hypophysectomy results in attenuation of the GH response to insulin associated with low or undetectable basal levels of GH (44). The diencephalic syndrome, a disorder frequently associated with lesions of the anterior hypothalamus, is characterized by elevated plasma GH levels and a paradoxical rise in GH secretion following glucose administration, reflecting dysregulation in hypothalamic GH-inhibiting pathways (45).

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment