Gliogenesis in adult brain

In the adult brain, in contrast to neurogenesis, gliogenesis occurs everywhere. New glial cells are born locally; and the locality also mainly determines the type of glial cell produced. In the subcortical white matter most of the newly produced glial cells are oligodendrocytes, whereas in the spinal cord astrocytes and oligodendrocytes are produced roughly in the same quantities.

Figure 7.1 Astrocytes as stem elements in the nervous system. In the adult CNS, 'stem' astrocytes can produce both neurones and glia. So far, it is almost impossible to distinguish between differentiated astrocytes and 'stem' astrocytes, and both retain mitotic potential. The precise pathways of transition of 'stem' astrocytes towards a glial or neuronal lineage are yet to be uncovered; however gliogenesis or neurogenesis can be promoted by various factors, some of which are listed

Figure 7.1 Astrocytes as stem elements in the nervous system. In the adult CNS, 'stem' astrocytes can produce both neurones and glia. So far, it is almost impossible to distinguish between differentiated astrocytes and 'stem' astrocytes, and both retain mitotic potential. The precise pathways of transition of 'stem' astrocytes towards a glial or neuronal lineage are yet to be uncovered; however gliogenesis or neurogenesis can be promoted by various factors, some of which are listed

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