Herbal Products

Toxicology and Clinical Pharmacology

Second Edition

Edited by

Timothy S. Tracy, PhD

Department of Experimental and Clinical Pharmacology University of Minnesota Minneapolis, MN

Richard L. Kingston, PharmD

SafetyCall International, PLLC Clinical Services Bloomington, MN

Humana Press Totowa, New Jersey

© 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com

All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher.

The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents.

This publication is printed on acid-free paper. C^)

ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Production Editor: Amy Thau Cover design by Nancy K. Fallatt

Cover Illustration: Fig. 1, Chapter 13, "Hawthorn," by Timothy S. Tracy

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Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1

eISBN 10-digit: 1-59745-383-8 eISBN 13-digit: 978-1-59745-383-7

Library of Congress Cataloging in Publication Data Herbal products : toxicology and clinical pharmacology / edited by Timothy S. Tracy, Richard L. Kingston. -- 2nd ed. p. ; cm. -- (Forensic science and medicine) Rev. ed. of: Toxicology and clinical pharmacology of herbal products / edited by Melanie Johns Cupp. c2000.

Companion to: Dietary supplements / edited by Melanie Johns Cupp and Timothy S. Tracy. c2003. Includes bibliographical references and index. ISBN 10-digit: 1-58829-313-0 (alk. paper) ISBN 13-digit: 978-1-58829-313-8 (alk. paper) 1. Herbs--Toxicology. 2. Materia medica, Vegetable--Toxicology. I. Tracy, Timothy S. II. Kingston, Richard L. III. Toxicology and clinical pharmacology of herbal products. IV. Dietary supplements. V. Series.

[DNLM: 1. Plants, Medicinal. 2. Phytotherapy--adverse effects. 3. Plant Extracts--pharmacology. 4. Plants, Medicinal--adverse effects. QV 766 H5347 2007] RA1250.T68 2007 615.9'52--dc22

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