Metabolism Elimination

The half-life of the flavonol glycosides administered as the product LI 1370 is 2-4 hours (19). Similar results wereobtained using 80 mg of the product EGb 761; half-lives of ginkgolides A and B were 4 and 6 hours, respectively. The half-life of bilobalide was 3 hours after administration of 120 mg of this extract. Similar results were reported in another study (52) using this same product; mean half-lives of ginkgolide A, ginkgolide B, and bilobalide were 4.5, 10.57, and 3.21 hours, respectively.

A study in rats using radiolabeled EGb 761 revealed a half-life of 4.5 hours, with elimination following first-order (linear) kinetics (19).

Approximately 70% of ginkgolide A, 50% of ginkgolide B, and 30% of bilobalide is excreted unchanged in the urine (19). Metabolites isolated from human urine after administration of EGb include a 4-hydroxybenzoic acid conjugate, 4-hydroxyhippuric acid, 3-methoxy-4-hydroxyhippuric acid, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, hippuric acid, and 3-methoxy-4-hydroxybenzoic acid (vanillic acid) (53). In accord with previous data, these metabolites accounted for less than 30% of the administered EGb dose. Metabolites were not detectable in blood samples.

Berry Boosters

Berry Boosters

Acai, Maqui And Many Other Popular Berries That Will Change Your Life And Health. Berries have been demonstrated to be some of the healthiest foods on the planet. Each month or so it seems fresh research is being brought out and new berries are being exposed and analyzed for their health giving attributes.

Get My Free Ebook

Post a comment