Metabolism Elimination

Several kava lactones have been identified in human urine samples after ingestion of a kava beverage prepared from a commercial 450-g sample of P. methysticin extracted with 3 L of room temperature water (31). Observed metabolic transformations include reduction of the 3,4 double bond and/or demethylation of the 4-methoxyl group on the a-pyrone ring system. Demethylation of the 12-methoxy substituent in yangonin and hydroxylation at carbon 12 of desmethoxyyangonin have also been observed. Chemical structures for these kava components and metabolites can be seen in the cited reference.

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