Vascular Permeability

In a rat model of hypertension, animals pretreated with V. myrtillus dry extract (Merck-Sharp and Dohme, Chibret, France) "rich in anthocyanin glu-cosides" at a dose of 50 mg/100 g body weight for 12 days prior to aortic ligation and for 14 days thereafter showed less permeability of the aorta, blood-brain barrier, and blood vessels of the skin to a tracer dye (1% tryptan blue solution), compared to untreated animals on day 7 after ligature (7). The effect was most pronounced in the brain and least pronounced in the blood vessels of the skin. The investigators proposed, based on previous experiments, that anthocyanins in bilberry extract interact with collagen to make it more resistant to the effects of collagenase, thus preserving the integrity of the basal lamina and its control of vascular permeability.

In a subsequent experiment (5), intraperitoneal injection of Myrtocyan ameliorated histamine-induced capillary permeability measured by permeability to Evans blue. The minimum effective dose was 50 mg/kg (p < 0.01 compared to control, Dunnett t-test). At a dose of200 mg/kg Myrtocyan was effective in improving capillary resistance to vacuum-induced petechiae in rats fed a flavonoid deficient diet (p < 0.01 compared to baseline, Dunnett t-test).

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