Types of MS Lesions

On the basis of topographical distribution of macrophages, and the type of myelin degradation products present within the macrophage, four types of MS plaques can be distinguished (Figure 4). The acute active plaque'' is characterized by the presence of macrophages containing early and late myelin degradation products, distributed throughout the extent of the lesion. The radially expanding ''active rim'' shows the accumulation of numerous macrophages, containing both early and late myelin...

Neurological Disease And Therapy

Professor of Neurology Harvard University School of Medicine Beth Israel Deaconess Medical Center Boston, Massachusetts, U.S.A. John C. Morris, M.D. Friedman Professor of Neurology Director, Alzheimer's Disease Research Center Washington University School of Medicine St. Louis, Missouri, U.S.A. Professor of Neurology Director, Movement Disorders Program Medical College of Georgia Augusta, Georgia, U.S.A. Professor of Neurosciences Director, Center for Neural Repair University of California-San...

Marburg MS

The Marburg variant of MS, recognized as a fulminant and lethal subtype of multiple sclerosis by Otto Marburg in 1906 (138), is characterized by rapid progression and an exceptional severity. The course is generally monophasic and relentlessly progressive, with death consequent to brainstem involvement or mass effect with herniation. Peripheral nervous system involvement may also occur in this variant of MS. Pathologically, the lesions are more destructive than typical MS and characterized by a...