Natural Scleroderma Relief

Natural Scleroderma Relief

Here's a quick look at what this new report covers: Calcium deposits (Calcinosis) noticible on the top layre of skin. How to permanently kill all the pathogenic nano bacteria using an easy to find supermarket product. A simple procedure which will stop the pathogenic bugs from ever returning. The easiest way to rid your body of all its harmful toxins & pollutants. Treating bacterial and fungal problems associated with the gastro-Intestinal tract naturally. A simple detoxification and cleansing agent for the kidneys. Re-build and strengthen your Immune-system. Restore your digestive system to its normal healthy state. Expelling excess free radicals from your body. Removing heavy metals deposits trapped in your body. Dealing with your depression. Re-charging your energy levels. Ease joints. Break down & remove excess calcium from your body without any medical intervention. Stop Acid Reflux problems in days without drugs

Natural Scleroderma Relief Summary


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Sclerodermalike Skin Changes

Skin changes were first clearly described in the patient series reported by Thannhauser, who distinguished changes in WS patients from those commonly seen in scleroderma patients or in patients with RothmundThomson syndrome (Thannhauser, 1945). The histologic appearance of skin biopsies from WS patients reveals an interesting mix of atrophic and proliferative changes. There is epidermal atrophy that extends to include skin appendages (e.g., hair follicles, sweat and sebaceous glands), in conjunction with focal hyperkeratosis and basal hypermelanosis. Dermal subcutaneous connective tissue atrophy is common, and often is found in conjunction with dermal fibrosis. Muscle, adipose, and connective tissue underlying the skin is often atrophic. This constellation of changes gives the skin a tight, white, and shiny or contracted appearance, with a loss of normal elasticity. Figure 80.1 Skin and soft tissue changes in Werner syndrome patients. A. Scleroderma-like skin changes,...


As in SLE, changes in the skin are the most obvious manifestations of scleroderma in the head and neck. In systemic sclerosis, the skin changes can begin with a sometimes pruritic, edematous phase, as inflammatory cells and fibroblasts are activated and cytokines are released. The skin in the affected areas tightens, loses flexibility, and thickens. In systemic sclerosis, characteristic facies may be noted, with a pursed-lip appearance and reduction in the oral aperture (Fig. 4). After several years, thinning and atrophy occur. Pigmentation changes may occur as well, giving a salt and pepper appearance. The dramatic en coup de sabre lesion (Fig. 5) is rare and is a manifestation of localized scleroderma. A nondermatomal fibrotic band infiltrates skin, subcutaneous fat, fascia, and muscle in the midline of the face, giving the appearance of a sword wound. Telangiectasias may be prominent on the head and neck, including involvement of the palate, oral mucosa, and tongue (Fig. 6)....

Mixed Connective Tissue Disease

Mixed connective tissue disease is characterized by a combination of overlapping features of systemic lupus erythematous, scleroderma, and polymyositis. Typical presentation is with Raynaud's phenomenon, arthralgias, inflammatory myopathy, lymphadenitis, skin or mucosal lesions, and serositis. A key distinguishing factor of the disorder is a high titer of antibody to ribonucleoprotein, a finding absent in any of these three disorders (SLE, scleroderma, and polymyositis). Neurologic dysfunction is present in approximately 10 to 15 of cases, usually presenting with facial pain, facial paresthesias, or aseptic meningitis (96,97). Facial nerve involvement, although far less common than trigeminal nerve involvement, has been described and is felt to be an early manifestation of the disorder (98). Although CSF analysis has suggested an inflammatory involvement of

Werner Syndrome as a Model of Human Aging

Werner syndrome (WS) is an uncommon, autosomal recessive human disease that displays clinical features suggestive of premature aging. The initial description of WS was by Otto Werner, a German medical student, in 1904 (Werner, 1985). Werner saw a family in the north of Germany consisting of four siblings, ages 31 to 40, who shared common features including short stature, premature graying of the hair, bilateral cataracts, skin changes (hyperkeratosis, scleroderma-like changes and ulceration) that were most severe on the feet and ankles, atrophy of the extremities, and, in females, an early scleroderma-line skin changes probable short stature, bilateral cataracts and scleroderma-like skin changes, any two other clinical, history or laboratory findings possible bilateral cataracts or scleroderma-like skin changes, any four other additional clinical, history or laboratory findings (1966) in their analyses of WS patients and pedigrees. Among the most consistent and earliest of the...

Methods for Applying Inoculum

Most commercially available AM bulk inoculum is a mixture of spores, colonized roots, hyphae, and the substrate on which pot cultures were grown. For EM fungi, many inoculation programs have successfully used the EM vegetative mycelium. The production of mycelial inoculum for large-scale inoculation programs is often costly and pure culture isolates can be difficult to maintain (Marx and Kenney 1982). In contrast, EM sporocarps contain a significant amount of spores that can be collected from the fruiting populations and easily dried and stored until application. Spores from EM fruiting bodies of Pisolithus, Scleroderma, and Rhizopogon are most frequently used as inoculum. Spores of Laccaria, Descolea, Scleroderma and Pisolithus spp. have recently been proposed as candidates for nursery inoculation programs for eucalypti (Lu et al. 1998) and Rhizopogon spp. are commonly used to inoculate Doulgas-fir seedlings in commercial nurseries (Castellano 1994).


Autoimmune disorders such as those discussed in this chapter are generally treated with immunosuppressive therapy. Corticosteroids are a mainstay of therapy in all of these disorders, but doses may vary widely, depending on the severity of disease manifestations. Among other immunosuppressives, those with more serious potential side effects are reserved for more severe disease manifestations. Often, however, the dermatologic manifestations of SLE and DM can be treated by hydroxychloroquine. This is a long-acting anti-inflammatory agent, not generally considered immunosuppressive, whose precise mechanism of action remains unclear. Hydroxychloroquine is frequently used alone or in combination with immunosuppressive therapy when skin rash is present however, it is not effective for the skin changes of scleroderma or the myositis of DM PM.


Systemic rheumatic disease may present with a variety of manifestations in the head and neck regions. Especially important among these are the dermatologic findings of SLE, DM, and scleroderma. Rashes characteristic of these disorders may also arise later in the course of the diseases. Some of the more frequently reported manifestations to be aware of are autoimmune hearing loss, especially in SLE esophageal dysmotility in scleroderma oropharyngeal and esophageal involvement in DM PM and keratoconjunctivitis sicca and cervical spine involvement in RA.


Conditions such as systemic lupus erythematosus, systemic sclerosis, and insulin autoimmune syndrome (Ito et al., 1993 Crow et al., 1994 Kuwana et al., 1995a). In both lupus and scleroderma, T-helper cells mediate antigen-specific autoanti-body production by B cells (Adams et al., 1991 Mohan et al., 1993 Kuwana et al., 1995b).