When the total blood hemoglobin concentration falls below normal in anemia, each red blood cell produces increased amounts of 2,3-DPG. A normal hemoglobin concentration of 15 g per 100 ml unloads about 4.5 ml O2 per 100 ml at rest, as previously described. If the hemoglobin concentration were reduced by half, you might expect that the tissues would receive only half the normal amount of oxygen (2.25 ml O2 per 100 ml). It has been shown, however, that an amount as great as 3.3 ml O2 per 100 ml is unloaded to the tissues under these conditions. This occurs as a result of a rise in 2,3-DPG production that causes a decrease in the affinity of hemoglobin for oxygen.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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