Antigens

Antigens are molecules that stimulate the production of specific antibodies and combine specifically with the antibodies produced. Most antigens are large molecules (such as proteins) with a molecular weight greater than about 10,000, although there are important exceptions. Also, most antigens are foreign to the blood and other body fluids. This is because the immune system can distinguish its own "self" molecules from those of any other organism ("nonself") and normally mounts an immune response only against nonself antigens. The ability of a molecule to function as an antigen depends not only on its size but also on the complexity of its structure. The plastics used in artificial implants are composed of large molecules, but they are not very antigenic because of their simple, repeating structures.

A large, complex molecule can have a number of different antigenic determinant sites, which are areas of the molecule that stimulate production of, and combine with, different antibodies. Most naturally occurring antigens have many antigenic determinant sites and stimulate the production of different antibodies with specificities for these sites.

■ Figure 15.3 The life cycle of the human immunodeficiency virus (HIV). This virus, like others of its family, contains RNA instead of DNA. Once inside the host cell, the viral RNA is transcribed by reverse transcriptase into complementary DNA (cDNA). The genes in the cDNA then direct the synthesis of new virus particles.

Antibodies attached to latex particles

Antibodies attached to latex particles

Agglutination (clumping) of latex particles

■ Figure 15.4 An immunoassay using the agglutination technique.

Antibodies against a particular antigen are adsorbed to latex particles. When these are mixed with a solution that contains the appropriate antigen, the formation of the antigen-antibody complexes produces clumping (agglutination) that can be seen with the unaided eye.

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