Secretion of Bile

The liver secretes bile continuously, but this secretion is greatly augmented following a meal. The increased secretion is due to the release of secretin and CCK from the duodenum. Secretin stimulates the liver to secrete bicarbonate into the bile, and CCK enhances this effect. The arrival of chyme in the duodenum also causes the gallbladder to contract and eject bile. Contraction of the gallbladder occurs in response to neural reflexes from the duodenum and to hormonal stimulation by CCK.

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