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Clinical Investigation

Timothy is only eighteen years old, but appears to have liver disease. A liver biopsy is performed, and different microscopic techniques are employed for viewing the samples.The biopsy reveals an unusually extensive smooth endoplasmic reticulum. In addition, an abnormally large amount of glycogen granules are found, and many intact glycogen granules are seen within secondary lysosomes.

Upon questioning, Timothy admits that he has a history of drug abuse, but claims that he is now in recovery. Laboratory analysis reveals that he has an abnormally low amount of the enzyme that hydrolyzes glycogen.What is the relationship between these observations?

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