Full thickness biopsy is a peroperative or laparoscopic biopsy (muscularis-containing biopsy) used to diagnose motility disturbances. One incision is situated below the umbilicus, and one in the left fossa. The bowel loop is identified laparoscopically, and will then be exteriorized through the incision below the umbilicus. The full thickness biopsy of at least 10X10 mm will then be taken with a surgical knife. The bowel loop is closed with absorbable sutures, and repositioned into the abdomen (56). Drawbacks of biopsies taken at surgery are the manipulation of the patients' diet (fasting), and the bowel preparation or preoperative treatment with antibiotics (29,58). Biopsies taken at surgery have the advantage of larger sample size than endoscopic biopsies, and various analyses may be applied such as molecular typing of bacteria in intestinal tissue of Crohn's patients (59).
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