F

Factorial designs, 3, See also Reaction optimization FcyRs, 73-74

amino acid sequence variants, 75-76 avidity effect, 77 glycan optimization, 76 IgG isotypes, 74-75 Feedback inhibition, 16-17 Flow cytometry, 95 5-Fluorouridine, 80

Forward genetics, gene discovery and, 92-103 gain-of-function screens, 96-98 loss-of-function screens, 98 antisense libraries, 98-100 peptide random sequence libraries, 101-102

random fragment libraries, 100-101 ribozyme random sequence libraries, 101 RNAi expression libraries, 102-103 phenotypic bioassays, 94-95 vectors, 94

Forward-phase protein microarrays, 119-120 Fucose, 76

Functional genomics, 91-107, 116, See also

Forward genetics, gene discovery and; Reverse genetics, novel gene validation and

Functional informatics, 1, 56 Functional MRI, 27

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