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aThe four highly conserved regions are shown with the number of the residue at which they begin. Shaded areas correspond to the residues that deviate from the conserved sequences. Symbol x indicates residues that, when replaced, abolish the catalytic activity [11].

aThe four highly conserved regions are shown with the number of the residue at which they begin. Shaded areas correspond to the residues that deviate from the conserved sequences. Symbol x indicates residues that, when replaced, abolish the catalytic activity [11].

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