Identification and Characterization of FET3

Using a selection system that was enriched for mutants unable to grow on low-iron media, Askwith et al. reported the identification of a mutant, fet3, that was unable to grow on low-iron media (14). This mutant had a normal surface reductase activity but was unable to accumulate 59Fe. A gene that could complement both the low-iron growth defect and the inability to accumulate radioactive iron was identified by complementation of the mutant strain with a genomic library. Genetic studies...

Copper And Neurodegenerative Diseases

Some very interesting recent findings have linked copper to various devastating neurological conditions and a common theme that emerges is the possibility of Cu-induced free-radical production leading to neuronal damage. Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurones, leads to progressive muscular weakness, atrophy, and death. An autosomal dominant form of ALS is caused by mutations in Cu Zn superoxide dismutase (SOD). It appears that the disease...

Cisca Wijmenga

Inherited liver cirrhosis is rarely observed in infancy or childhood in Western countries, but, recently, 138 cases of an endemic form of infantile cirrhosis were reported from several families in the Tyrol, Austria. These infants had received high amounts of dietary copper released from copper vessels used to prepare their formula milk. Extensive studies in this Tyrolean population suggested that the so-called non-Indian childhood cirrhosis (NICC) occurred only in children with a genetic...

C

CAB45584, Streptomyces, 519 CAB50963, Streptomyces, 519, 520 Caco-2 cell, see Intestine Cadherin, see E-cadherin Calcium, copper effects in aquatic organism homeostasis, 424-426 organisms, 419, 420, 424 P-type ATPase homology, 264 Cancer, angiogenesis, see Angiogenesis copper metabolism, 24, 25 Cartilage matrix glycoprotein CMGP , copper binding and function, 21 Ccc2, Atxl interactions, 574 Chlamydomonas reinhardtii, 494 copper, loading of Fet3p, 241, 574 transport, 227 CCH, Atx1 homology, 552...

References

Kumar, S., Rowse, C., and Hochstein, P. 1978 Copper-induced generation of superoxide in human red cell membrane. Biochem. Biophys. Res. Commun. 83, 587-593. 2. Linder, M. C. 1991 Biochemistry of Copper. Biochemistry of the Elements Frieden, E., ed. , Plenum, New York. 3. Linder, M. C., Lomeli, N. A., Donley, S., Mehrbod, F., Cerveza, P., Cotton, S., et al. 1999 Copper transport in mammals. Adv. Exp. Biol. Med. 448, 1-16. 4. Danks, D. M. 1995 Disorders of copper transport, in The Metabolic...