Copper And Neurodegenerative Diseases

Some very interesting recent findings have linked copper to various devastating neurological conditions and a common theme that emerges is the possibility of Cu-induced free-radical production leading to neuronal damage. Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurones, leads to progressive muscular weakness, atrophy, and death. An autosomal dominant form of ALS is caused by mutations in Cu Zn superoxide dismutase (SOD). It appears that the disease...

C

CAB45584, Streptomyces, 519 CAB50963, Streptomyces, 519, 520 Caco-2 cell, see Intestine Cadherin, see E-cadherin Calcium, copper effects in aquatic organism homeostasis, 424-426 organisms, 419, 420, 424 P-type ATPase homology, 264 Cancer, angiogenesis, see Angiogenesis copper metabolism, 24, 25 Cartilage matrix glycoprotein CMGP , copper binding and function, 21 Ccc2, Atxl interactions, 574 Chlamydomonas reinhardtii, 494 copper, loading of Fet3p, 241, 574 transport, 227 CCH, Atx1 homology, 552...

References

Kumar, S., Rowse, C., and Hochstein, P. 1978 Copper-induced generation of superoxide in human red cell membrane. Biochem. Biophys. Res. Commun. 83, 587-593. 2. Linder, M. C. 1991 Biochemistry of Copper. Biochemistry of the Elements Frieden, E., ed. , Plenum, New York. 3. Linder, M. C., Lomeli, N. A., Donley, S., Mehrbod, F., Cerveza, P., Cotton, S., et al. 1999 Copper transport in mammals. Adv. Exp. Biol. Med. 448, 1-16. 4. Danks, D. M. 1995 Disorders of copper transport, in The Metabolic...