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Adapted from Ref. 56.

Adapted from Ref. 56.

The proportion (prevalence) of carcinogens in the database strongly influences the performance characteristics evaluated. For example, if a test has a low sensitivity and high specificity, it will perform well when the proportion of carcinogens in the database is low. Alternatively, if the test is highly sensitive with low specificity, it will perform well when the proportion of carcinogens is high and poorly when the proportion is low.

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