The CD4 molecule is the major receptor for HIV-1 for entry into T lymphocytes. Thus, in a similar way to RNA decoys, mutant CD4, which stays inside the endoplasmatic reticulum, has been shown to inactivate HIV-1 envelope maturation, preventing formation of infectious particles. In another approach, soluble CD4 has been used to block the envelope of free extracellular virus particles and to prevent binding to fresh target cells. However, the question remains whether soluble and/or mutant CD4 in the blood of the patient will also serve as a trap for natural CD4 ligands leading to the impairment of important physiological functions.69-71
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